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CS-W001157 4
Total: USD 88.00

3-Methoxypicolinaldehyde

  • CAS No. 1849-53-2

  • Cat. No. CS-W021956
  • Purity≥96%
  • MDL No.MFCD05664031

*For research and further manufacturing use only, not for direct human use.

3-Methoxypicolinaldehyde|CS-W021956

Structure of 1849-53-2

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General Information

  • CAS No. 1849-53-2
  • Cat. No. CS-W021956
  • Purity ≥96%
  • MDL No. MFCD05664031
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 3-Methoxypyridine-2-carbaldehyde
  • SMILES COC1=CC=CN=C1C=O

Description

3-Methoxypicolinaldehyde features a pyridine ring with strategically positioned aldehyde and methoxy groups, enabling direct incorporation into bioactive scaffolds. The electron-withdrawing aldehyde enhances reactivity in nucleophilic addition reactions, while the para-methoxy substituent improves solubility and stability under standard conditions. This compound serves as a key building block for pharmaceutical intermediates and functional materials.

Application

3-Methoxypicolinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based heterocycles. Its aldehyde functionality facilitates nucleophilic additions and condensation reactions, while the methoxy group enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for multi-step synthesis and scale-up applications.

Synthesis

  • Route1

    References

    • Tetrahedron, , vol. 61, # 3 p. 643 - 655
  • Route2

    References

    • Tetrahedron Letters, , vol. 29, # 7 p. 773 - 776
  • Route3
    • In-stock
      3-Methoxypyridine|CS-W008119
      7295-76-3
    • null|null
      68-12-2
    • ~%
    • In-stock
      3-Methoxypicolinaldehyde|CS-W021956
      1849-53-2

    References

    • Journal of Organic Chemistry, , vol. 55, # 1 p. 69 - 73

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   0.9027
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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