1-Boc-4-Chlorosulfonylpiperidine

Name: 1-Boc-4-Chlorosulfonylpiperidine
Brand: ChemScene
Availability: InStock
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CAS No. 782501-25-1
Cat. No. CS-W002841
Purity≥97%
MDL No.MFCD01861750

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Boc-4-Chlorosulfonylpiperidine|CS-W002841

Structure of 782501-25-1

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General Information

CAS No. 782501-25-1
Cat. No. CS-W002841
Purity ≥97%
MDL No. MFCD01861750
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈ClNO₄S
Molecular Weight 283.77
Synonym(s) Tert-butyl 4-(chlorosulfonyl)piperidine-1-carboxylate
SMILES O=C(N1CCC(CC1)S(=O)(=O)Cl)OC(C)(C)C

Description

1-Boc-4-Chlorosulfonylpiperidine features a protected piperidine core with a chlorosulfonyl group, enabling direct incorporation into sulfonamide synthesis. This bench-stable reagent facilitates efficient derivatization under mild conditions, offering high functional group tolerance and clean reaction profiles in medicinal chemistry applications.

Application

1-Boc-4-chlorosulfonylpiperidine serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and bioactive molecules. The chlorosulfonyl group enables direct displacement reactions with amines, facilitating rapid access to sulfonamide derivatives under mild conditions. The Boc protecting group ensures stability during multistep syntheses and can be selectively removed at late stages. This reagent exhibits excellent functional group tolerance and is compatible with standard bench-scale procedures, making it ideal for medicinal chemistry campaigns and API intermediate development.

Synthesis

Route1
- 141699-66-3
- ~%
- In-stock
  
  782501-25-1
References
- US2008/76758 A1, ; Page/Page column 86 ; US 20080076758 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.68
LogP 1.9545
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-Boc-4-Chlorosulfonylpiperidine

CAS No. 782501-25-1

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