Lot numbers can be found on the outside label of a product:
(3-Methoxypyridin-2-yl)methanol
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CAS No. 51984-46-4
- Cat. No. CS-0044028
- Purity≥98%
- MDL No.MFCD08234494
*For research and further manufacturing use only, not for direct human use.
Structure of 51984-46-4
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General Information
- CAS No. 51984-46-4
- Cat. No. CS-0044028
- Purity ≥98%
- MDL No. MFCD08234494
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₉NO₂
- Molecular Weight 139.15
- Synonym(s) 3-methoxy-2-pyridyl)methanol
- SMILES OCC1=NC=CC=C1OC
Description
(3-Methoxypyridin-2-yl)methanol features a pyridine ring bearing a methoxy group at the 3-position and a hydroxymethyl substituent at the 2-position. This configuration imparts enhanced solubility and stability under standard conditions, enabling direct incorporation into synthetic sequences without protective group manipulation. The compound serves as a key building block for bioactive heterocycles and functionalized ligands in medicinal chemistry applications.
Application
(3-Methoxypyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine derivatives. Its pendant hydroxymethyl group facilitates straightforward derivatization via oxidation, etherification, or coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it suitable for multi-step synthesis workflows requiring orthogonality and predictable reactivity.
Synthesis
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Route1
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In-stock
31224-43-8 -
124-41-4 - ~45%
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In-stock
51984-46-4
References
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ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2009/27746 A1, 2009 ; Location in patent: Page/Page column 115 ; WO 2009/027746 A1
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Route2
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In-stock
14173-30-9 -
74-88-4
- ~41%
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In-stock
51984-46-4
References
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Russell, Michael G. N.; Carling, Robert W.; Atack, John R.; Bromidge, Frances A.; Cook, Susan M.; Hunt, Peter; Isted, Catherine; Lucas, Matt; McKernan, Ruth M.; Mitchinson, Andrew; Moore, Kevin W.; Narquizian, Robert; Macaulay, Alison J.; Thomas, David; Thompson, Sally-Anne; Wafford, Keith A.; Castro, Jose L. Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1367 - 1383
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Route3
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In-stock
24059-83-4 - ~%
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In-stock
51984-46-4
References
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Smith Kline and French Laboratories Limited Patent: US4083983 A1, 1978 ; US 4083983 A
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 42.35
- LogP 0.5825
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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