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CS-W001157 4
Total: USD 88.00

3-Amino-4-fluorophenylboronic acid

  • CAS No. 873566-75-7

  • Cat. No. CS-0157158
  • Molecule weight154.93
  • Purity≥95%
  • MDL No.MFCD03092925

*For research and further manufacturing use only, not for direct human use.

3-Amino-4-fluorophenylboronic acid|CS-0157158

Structure of 873566-75-7

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General Information

  • CAS No. 873566-75-7
  • Cat. No. CS-0157158
  • Purity ≥95%
  • MDL No. MFCD03092925
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BFNO₂
  • Molecular Weight 154.93
  • Synonym(s) 3-Amino-4-fluorophenylboronicacid
  • SMILES C1=CC(=C(C=C1B(O)O)N)F

Description

3-Amino-4-fluorophenylboronic acid features a strategically positioned amino group and fluorine atom that enhance electronic modulation and metabolic stability. This boronate moiety enables efficient Suzuki-Miyaura coupling under mild conditions, delivering high-yield biaryl constructions in medicinal chemistry and materials synthesis.

Application

3-Amino-4-fluorophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The ortho-fluoro and amino groups provide directed metalation and enhanced reactivity, while the boronic acid functionality offers excellent bench stability and compatibility with diverse functional groups. Its utility spans medicinal chemistry and materials science, facilitating rapid access to substituted aromatic systems with predictable regiochemistry.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.48
  • LogP   -0.9123
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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