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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-(trifluoromethyl)pyridine

  • CAS No. 39891-02-6

  • Cat. No. CS-0040112
  • Purity≥97%
  • MDL No.MFCD10698621

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-(trifluoromethyl)pyridine|CS-0040112

Structure of 39891-02-6

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General Information

  • CAS No. 39891-02-6
  • Cat. No. CS-0040112
  • Purity ≥97%
  • MDL No. MFCD10698621
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂F₃N
  • Molecular Weight 215.99
  • Synonym(s) None
  • SMILES FC(C1=CC(Cl)=CC(Cl)=N1)(F)F

Description

2,4-Dichloro-6-(trifluoromethyl)pyridine features a strongly electron-deficient pyridine core enhanced by orthogonal chlorine and trifluoromethyl substituents. This combination imparts high reactivity in cross-coupling processes and excellent stability under standard bench conditions. The molecule serves as a key building block for pharmaceutical intermediates and agrochemicals.

Application

2,4-Dichloro-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The electron-deficient pyridine core exhibits high reactivity toward nucleophilic substitution, with the trifluoromethyl group enhancing metabolic stability and lipophilicity. Bench-stable and readily purified, it functions effectively in Suzuki, Stille, and Buchwald-Hartwig coupling protocols, facilitating rapid access to complex target molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4072
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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