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tert-Butyl (S)-3-(methoxymethyl)piperazine-1-carboxylate

  • CAS No. 955400-16-5

  • Cat. No. CS-0029663
  • Purity≥98%
  • MDL No.MFCD15072107

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (S)-3-(methoxymethyl)piperazine-1-carboxylate|CS-0029663

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General Information

  • CAS No. 955400-16-5
  • Cat. No. CS-0029663
  • Purity ≥98%
  • MDL No. MFCD15072107
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight 230.30
  • Synonym(s) tert-butyl (3S)-3-(methoxymethyl)piperazine-1-carboxylate
  • SMILES O=C(N1C[C@@H](COC)NCC1)OC(C)(C)C

Description

tert-Butyl (S)-3-(methoxymethyl)piperazine-1-carboxylate is a bench-stable, moisture-tolerant chiral building block featuring a piperazine core with a methoxymethyl substituent. This configuration enables selective functionalization in medicinal chemistry, particularly for modulating solubility and metabolic stability in bioactive molecule synthesis.

Application

tert-Butyl (S)-3-(methoxymethyl)piperazine-1-carboxylate serves as a chiral piperazine building block, enabling efficient access to diverse nitrogen-containing scaffolds. Its methoxymethyl group provides orthogonal protection for the piperazine nitrogen, facilitating selective functionalization and downstream deprotection under mild acidic conditions. The tert-butyl carbamate offers excellent bench stability and compatibility with standard coupling reactions, making it ideal for medicinal chemistry campaigns requiring precise stereocontrol and functional group manipulation.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.8
  • LogP   0.8417
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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