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CS-W001157 4
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1-Boc-3-hydroxymethyl-piperazine

  • CAS No. 301673-16-5

  • Cat. No. CS-D0661
  • Purity≥97%
  • MDL No.MFCD04115304

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-hydroxymethyl-piperazine|CS-D0661

Structure of 301673-16-5

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General Information

  • CAS No. 301673-16-5
  • Cat. No. CS-D0661
  • Purity ≥97%
  • MDL No. MFCD04115304
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) Tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N1CC(CO)NCC1

Description

1-Boc-3-hydroxymethyl-piperazine features a protected piperazine core with a hydroxymethyl side chain, enabling straightforward deprotection and functionalization. This bench-stable derivative integrates readily into diverse synthetic sequences, particularly in medicinal chemistry scaffolds requiring nitrogen-rich heterocycles with orthogonal handling.

Application

1-Boc-3-hydroxymethyl-piperazine serves as a versatile building block in medicinal chemistry, enabling the introduction of a hydroxymethyl-functionalized piperazine scaffold. The Boc group provides stability and ease of deprotection under mild acidic conditions, while the primary alcohol functionality supports further derivatization via esterification, etherification, or oxidation to aldehyde. Its compatibility with standard coupling reactions and robust bench stability facilitate efficient synthesis of complex heterocyclic systems and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   0.1876
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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