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CS-W001157 4
Total: USD 88.00

2-Amino-N,N-dimethylacetamide

  • CAS No. 1857-19-8

  • Cat. No. CS-B0440
  • Purity≥95%
  • MDL No.MFCD06655264

*For research and further manufacturing use only, not for direct human use.

2-Amino-N,N-dimethylacetamide|CS-B0440

Structure of 1857-19-8

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General Information

  • CAS No. 1857-19-8
  • Cat. No. CS-B0440
  • Purity ≥95%
  • MDL No. MFCD06655264
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀N₂O
  • Molecular Weight 102.14
  • Synonym(s) N,N-Dimethyl-2-aminoacetamide
  • SMILES O=C(CN)N(C)C

Description

2-Amino-N,N-dimethylacetamide features a polar amine group flanked by two methyl-substituted alkyl chains, delivering enhanced solubility and stability under standard conditions. This structure enables efficient integration into peptide coupling protocols and synthetic intermediates for pharmaceutical applications.

Application

2-Amino-N,N-dimethylacetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds through standard amide coupling and cyclization protocols. Its N,N-dimethylamino group enhances solubility and reactivity, while the primary amine facilitates conjugation and derivatization under mild conditions. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step synthesis workflows for API intermediates and targeted compound libraries.

Synthesis

  • Route1
    • Benzyl (2-(dimethylamino)-2-oxoethyl)carbamate|CS-0539669
      167303-60-8
    • ~91%
    • In-stock
      2-Amino-N,N-dimethylacetamide|CS-B0440
      1857-19-8

    References

    • Gaeta, Alessandra; Molina-Holgado, Francisco; Kong, Xiao L.; Salvage, Sarah; Fakih, Sarah; Francis, Paul T.; Williams, Robert J.; Hider, Robert C. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 3 p. 1285 - 1297
  • Route2
    • In-stock
      Oxazolidine-2,5-dione|CS-W011320
      2185-00-4
    • null|null
      124-40-3
    • ~%
    • In-stock
      2-Amino-N,N-dimethylacetamide|CS-B0440
      1857-19-8

    References

    • Journal of the Chemical Society, , p. 3009,3011

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.33
  • LogP   -0.9667
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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