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tert-Butyl (R)-3-(methoxymethyl)piperazine-1-carboxylate

  • CAS No. 1359658-32-4

  • Cat. No. CS-0079217
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD19688482

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (R)-3-(methoxymethyl)piperazine-1-carboxylate|CS-0079217

Structure of 1359658-32-4

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General Information

  • CAS No. 1359658-32-4
  • Cat. No. CS-0079217
  • Purity ≥95%
  • MDL No. MFCD19688482
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight None
  • Synonym(s) tert-butyl (3R)-3-(methoxymethyl)piperazine-1-carboxylate
  • SMILES O=C(N1C[C@H](COC)NCC1)OC(C)(C)C

Description

tert-Butyl (R)-3-(methoxymethyl)piperazine-1-carboxylate features a chiral piperazine core with a methoxymethyl side chain and bench-stable tert-butyl carbamate protection. This configuration enables selective incorporation into complex scaffolds during peptide and small-molecule synthesis, particularly where stereocontrol and orthogonal functionality are required.

Application

tert-Butyl (R)-3-(methoxymethyl)piperazine-1-carboxylate serves as a stable, bench-ready chiral building block for medicinal chemistry and process development. Its piperazine core enables efficient functionalization in standard coupling reactions, while the tert-butyl carbamate group offers orthogonal protection compatible with diverse synthetic sequences. The methoxymethyl substituent provides enhanced solubility and facilitates selective deprotection under mild acidic conditions, streamlining access to functionalized piperazine derivatives used in API synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.8
  • LogP   0.8417
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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