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Structure of 954815-14-6
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Methyl 4-iodo-2-(trifluoromethyl)benzoate features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the iodine substituent enables facile cross-coupling reactions. This ortho-substituted aryl ester integrates readily into complex molecular architectures under standard conditions.
Methyl 4-iodo-2-(trifluoromethyl)benzoate serves as a versatile building block in cross-coupling chemistry, enabling efficient Pd-catalyzed transformations such as Suzuki, Stille, and Negishi reactions. The iodide functionality offers high reactivity under mild conditions, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step syntheses of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: