Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-Bromo-4-iodo-2-(trifluoromethyl)benzene

  • CAS No. 364-11-4

  • Cat. No. CS-0113118
  • Molecule weight350.90
  • Purity≥97%
  • MDL No.MFCD11855999

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-iodo-2-(trifluoromethyl)benzene|CS-0113118

Structure of 364-11-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 364-11-4
  • Cat. No. CS-0113118
  • Purity ≥97%
  • MDL No. MFCD11855999
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrF₃I
  • Molecular Weight 350.90
  • Synonym(s) 2-Bromo-5-iodobenzotrifluoride
  • SMILES FC(C1=CC(I)=CC=C1Br)(F)F

Description

1-Bromo-4-iodo-2-(trifluoromethyl)benzene features a trifluoromethyl group flanked by bromo and iodo substituents, enabling sequential cross-coupling reactions. This electron-deficient aromatic scaffold integrates readily into complex molecular architectures under standard conditions.

Application

1-Bromo-4-iodo-2-(trifluoromethyl)benzene serves as a versatile bifunctional aryl building block for palladium-catalyzed cross-coupling reactions. The bromo and iodo groups enable sequential or orthogonal coupling processes, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by column chromatography, it facilitates efficient construction of complex biaryl scaffolds and functionalized heterocycles in multi-step synthesis.

Synthesis

  • Route1
    • 4-Bromo-3-(trifluoromethyl)aniline Bicalutamide  Impurity|CS-0228847
      393-36-2
    • ~94%
    • In-stock
      1-Bromo-4-iodo-2-(trifluoromethyl)benzene|CS-0113118
      364-11-4

    References

    • UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA; UNIVERSITÉ DE GENÈVE; UNIVERSITÉ CLAUDE BERNARD - LYON 1; GAMBACORTI-PASSERINI, Carlo; MOLOGNI, Luca; SCAPOZZA, Leonardo; BISSON, William; AHMED, Shaheen; GOEKJIAN, Peter; TARDY, Sébastien; ORSATO, Alexandre; GUEYRARD, David; BENOIT, Joseph Patent: WO2013/167730 A1, 2013 ; Location in patent: Page/Page column 90 ;
  • Route2

    References

    • McBee et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3932
  • Route3
    • 1-Bromo-4-nitro-2-(trifluoromethyl)benzene Bicalutamide  Impurity|CS-0228846
      367-67-9
    • ~%
    • In-stock
      1-Bromo-4-iodo-2-(trifluoromethyl)benzene|CS-0113118
      364-11-4

    References

    • McBee et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 3932

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   0
  • LogP   4.0725
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 364-11-4 sigma364-11-4 manufacturer364-11-4 price364-11-4 structure364-11-4 SDSbuy 364-11-4364-11-4 supplier364-11-4 uses364-11-4 molecular weightprice of 364-11-4364-11-4 chemical name formula of 364-11-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label