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CS-W001157 4
Total: USD 88.00

6-Bromo-4-chloro-2-(trifluoromethyl)quinoline

  • CAS No. 1701-28-6

  • Cat. No. CS-0131687
  • Purity≥98%
  • MDL No.MFCD00153073

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-chloro-2-(trifluoromethyl)quinoline|CS-0131687

Structure of 1701-28-6

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General Information

  • CAS No. 1701-28-6
  • Cat. No. CS-0131687
  • Purity ≥98%
  • MDL No. MFCD00153073
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₄BrClF₃N
  • Molecular Weight 310.50
  • Synonym(s) None
  • SMILES FC(C1=NC2=CC=C(Br)C=C2C(Cl)=C1)(F)F

Description

6-Bromo-4-chloro-2-(trifluoromethyl)quinoline features a sterically hindered quinoline core with complementary halogen and trifluoromethyl groups, enabling direct functionalization in cross-coupling reactions. This bench-stable scaffold integrates readily into complex molecular architectures requiring electron-deficient heterocyclic platforms.

Application

6-Bromo-4-chloro-2-(trifluoromethyl)quinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. Its strategic halogenation pattern enables sequential functionalization via Pd-catalyzed couplings, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The compound exhibits excellent bench stability and facilitates efficient synthesis of complex quinoline-based scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   4.6695
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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