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CS-W001157 4
Total: USD 88.00

Boc-NH-Cyclobutane-COOH

  • CAS No. 946152-72-3

  • Cat. No. CS-W021751
  • Purity≥97%
  • MDL No.MFCD09864181

*For research and further manufacturing use only, not for direct human use.

Boc-NH-Cyclobutane-COOH|CS-W021751

Structure of 946152-72-3

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General Information

  • CAS No. 946152-72-3
  • Cat. No. CS-W021751
  • Purity ≥97%
  • MDL No. MFCD09864181
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄
  • Molecular Weight 215.25
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NC1CC(C(=O)O)C1

Description

This cyclobutanecarboxylic acid derivative features a tert-butoxycarbonyl-protected amine group, enabling stable incorporation into peptide synthesis workflows. The rigid cyclobutane scaffold imparts conformational constraint, while the Boc moiety ensures compatibility with standard deprotection protocols. Ideal for building bioactive peptidomimetics and cyclic scaffolds in medicinal chemistry.

Application

3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of cyclobutane-containing peptidomimetics and bioactive heterocycles. The Boc-protected amine and carboxylic acid functionalities offer orthogonal reactivity, facilitating sequential coupling strategies. Its bench-stable nature and compatibility with standard peptide synthesis protocols make it ideal for iterative fragment assembly and structure-activity studies.

Synthesis

  • Route1
    • Ethyl 3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate|CS-0679508
      946152-71-2
    • ~95%
    • In-stock
      Boc-NH-Cyclobutane-COOH|CS-W021751
      946152-72-3

    References

    • Roche Palo Alto LLC Patent: US2007/191406 A1, 2007 ; Location in patent: Page/Page column 37 ; US 20070191406 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   1.3743
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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