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trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid

  • CAS No. 939400-34-7

  • Cat. No. CS-0047808
  • Purity≥96%
  • MDL No.MFCD06657681

*For research and further manufacturing use only, not for direct human use.

trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid|CS-0047808

Structure of 939400-34-7

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General Information

  • CAS No. 939400-34-7
  • Cat. No. CS-0047808
  • Purity ≥96%
  • MDL No. MFCD06657681
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄
  • Molecular Weight 215.25
  • Synonym(s) None
  • SMILES N(C(OC(C)(C)C)=O)[C@H]1C[C@H](C(O)=O)C1

Description

trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid features a rigid cyclobutane core with a sterically protected Boc-amino group, enabling stable incorporation into peptide backbones. This configuration enhances solubility and simplifies purification during synthetic workflows.

Application

trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a stable, bench-ready building block for the synthesis of cyclobutane-containing peptidomimetics and bioactive heterocycles. The Boc-protected amine enables straightforward N-alkylation and coupling reactions, while the carboxylic acid facilitates direct amidation or esterification. Its trans stereochemistry provides defined conformational rigidity, enhancing structural predictability in target-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   1.3743
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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