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CS-W001157 4
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cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid

  • CAS No. 1008773-79-2

  • Cat. No. CS-W022613
  • Purity≥97%
  • MDL No.MFCD06657680

*For research and further manufacturing use only, not for direct human use.

cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid|CS-W022613

Structure of 1008773-79-2

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General Information

  • CAS No. 1008773-79-2
  • Cat. No. CS-W022613
  • Purity ≥97%
  • MDL No. MFCD06657680
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₇NO₄
  • Molecular Weight 215.25
  • Synonym(s) None
  • SMILES N(C(OC(C)(C)C)=O)[C@@H]1C[C@H](C(O)=O)C1

Description

cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid features a rigid, sterically constrained cyclobutane scaffold with a bench-stable Boc-protected amine and carboxylic acid functionality. This configuration enables direct incorporation into peptidomimetics and bioactive scaffolds where conformational rigidity enhances target affinity and metabolic stability.

Application

cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a versatile chiral building block for the synthesis of bioactive cyclobutane-containing scaffolds. The protected amine and carboxylic acid functionalities enable sequential derivatization, including orthogonal deprotection and coupling reactions. Its cis stereochemistry provides defined spatial orientation, facilitating controlled ring fusion in medicinal chemistry applications. Bench-stable and readily purified by standard chromatographic methods, it functions effectively in peptide-like fragment assembly and heterocycle construction.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   1.3743
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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