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cis-3-Aminocyclobutanecarboxylic acid hydrochloride

  • CAS No. 84182-59-2

  • Cat. No. CS-0043980
  • Purity≥97%
  • MDL No.MFCD09971691

*For research and further manufacturing use only, not for direct human use.

cis-3-Aminocyclobutanecarboxylic acid hydrochloride|CS-0043980

Structure of 84182-59-2

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General Information

  • CAS No. 84182-59-2
  • Cat. No. CS-0043980
  • Purity ≥97%
  • MDL No. MFCD09971691
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClNO₂
  • Molecular Weight 151.59
  • Synonym(s) hydrochloride
  • SMILES O=C(O)[C@H]1C[C@H](C1)N.[H]Cl

Description

cis-3-Aminocyclobutanecarboxylic acid hydrochloride features a rigid, strained cyclobutane core that enforces conformational control in bioactive molecules. The amine group enables direct derivatization, while the hydrochloride salt enhances solubility and handling stability under standard conditions. This scaffold delivers structural precision for medicinal chemistry applications.

Application

cis-3-Aminocyclobutanecarboxylic acid hydrochloride serves as a valuable chiral building block for medicinal chemistry and peptide-based drug discovery. Its constrained cyclobutane scaffold provides rigidity to modulate bioactive conformation, while the amino and carboxylic acid functionalities enable direct incorporation into peptidomimetics via standard amide coupling or derivatization protocols. The hydrochloride salt enhances solubility and stability under bench conditions, facilitating handling and purification in multi-step syntheses.

Synthesis

  • Route1
    • cis-3-Aminocyclobutanecarboxamide hydrochloride|CS-0533667
      84182-57-0
    • ~81%
    • In-stock
      cis-3-Aminocyclobutanecarboxylic acid hydrochloride|CS-0043980
      84182-59-2

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
  • Route2

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
  • Route3

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.2301
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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