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N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-methoxy-L-tryptophan

  • CAS No. 2416720-26-6

  • Cat. No. CS-1236039
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-methoxy-L-tryptophan|CS-1236039

Structure of 2416720-26-6

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General Information

  • CAS No. 2416720-26-6
  • Cat. No. CS-1236039
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₄N₂O₅
  • Molecular Weight 456.49
  • Synonym(s) None
  • SMILES COC1=C2C(C(C[C@@H](C(O)=O)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=CN2)=CC=C1

Description

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-methoxy-L-tryptophan is a protected amino acid derivative featuring a fluorenylmethoxycarbonyl group at the α-amino terminus and a methoxy substituent at the indole C7 position. This configuration enhances solubility in organic solvents and provides stability during peptide synthesis, enabling efficient incorporation into sequence-defined polypeptides under standard coupling conditions.

Application

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-methoxy-L-tryptophan serves as a protected amino acid building block for the synthesis of peptide conjugates and biologically active heterocycles. The Fmoc group enables orthogonal protection compatible with standard solid-phase peptide synthesis, while the 7-methoxy substitution on the indole ring enhances metabolic stability and modulates electronic properties. This derivative exhibits excellent bench stability, facilitates efficient purification, and participates reliably in coupling reactions under mild conditions, making it a practical choice for complex molecule assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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