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CS-W001157 4
Total: USD 88.00

(4-(Trifluoromethoxy)phenyl)methanamine

  • CAS No. 93919-56-3

  • Cat. No. CS-W013220
  • Purity≥95%
  • MDL No.MFCD00061237

*For research and further manufacturing use only, not for direct human use.

(4-(Trifluoromethoxy)phenyl)methanamine|CS-W013220

Structure of 93919-56-3

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General Information

  • CAS No. 93919-56-3
  • Cat. No. CS-W013220
  • Purity ≥95%
  • MDL No. MFCD00061237
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight None
  • Synonym(s) 4-(Trifluoromethoxy)benzylamine
  • SMILES NCC1=CC=C(OC(F)(F)F)C=C1

Application

(4-(Trifluoromethoxy)phenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the primary amine facilitates straightforward derivatization via coupling, alkylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for high-throughput screening and process-scale applications.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6197 - 6208

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.0439
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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