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CS-W001157 4
Total: USD 88.00

(3,4,5-Trifluorophenyl)methanamine

  • CAS No. 235088-69-4

  • Cat. No. CS-W014325
  • Purity≥98%
  • MDL No.MFCD00236318

*For research and further manufacturing use only, not for direct human use.

(3,4,5-Trifluorophenyl)methanamine|CS-W014325

Structure of 235088-69-4

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General Information

  • CAS No. 235088-69-4
  • Cat. No. CS-W014325
  • Purity ≥98%
  • MDL No. MFCD00236318
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃N
  • Molecular Weight 161.13
  • Synonym(s) 3,4,5-Trifluorobenzylamine
  • SMILES NCC1=CC(F)=C(F)C(F)=C1

Description

(3,4,5-Trifluorophenyl)methanamine features a trifluorophenyl ring with enhanced electron-withdrawing character, enabling robust coupling in cross-coupling reactions. This bench-stable amine integrates readily into bioactive scaffolds, offering improved metabolic stability and membrane permeability in medicinal chemistry applications.

Synthesis

  • Route1

    References

    • Doyon, Jeffrey B.; Jain, Ahamindra Organic Letters, 1999 , vol. 1, # 2 p. 183 - 185

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H226-H302-H314-H318
Precautionary Statements : P210-P240-P241-P280-P370+P378

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.5626
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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