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CS-W001157 4
Total: USD 88.00

1-Aminoindan

  • CAS No. 34698-41-4

  • Cat. No. CS-W007551
  • Purity≥95%
  • MDL No.MFCD00003799

*For research and further manufacturing use only, not for direct human use.

1-Aminoindan|CS-W007551

Structure of 34698-41-4

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General Information

  • CAS No. 34698-41-4
  • Cat. No. CS-W007551
  • Purity ≥95%
  • MDL No. MFCD00003799
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁N
  • Molecular Weight 133.19
  • Synonym(s) 1-Indanamine; 2,3-Dihydro-1H-inden-1-amine
  • SMILES NC1C2=C(CC1)C=CC=C2

Description

2,3-Dihydro-1H-inden-1-amine features a saturated indene core with a primary amine at the 1-position, delivering enhanced solubility and stability compared to aromatic analogs. This bench-stable scaffold integrates readily into diverse synthetic routes, serving as a key building block for pharmaceutical intermediates and functionalized heterocycles.

Application

2,3-Dihydro-1H-inden-1-amine serves as a versatile scaffold in medicinal chemistry, enabling the construction of diverse heterocyclic systems through standard functionalization protocols. Its benzylic amine functionality offers reliable reactivity in nucleophilic substitution and coupling reactions, while its inherent stability facilitates handling and purification. The compound functions as a key building block for bioactive molecules, particularly in the development of kinase inhibitors and CNS-targeted therapeutics.

Synthesis

  • Route1
    • null|null
      68253-35-0
    • ~94%
    • In-stock
      1-Aminoindan|CS-W007551
      34698-41-4

    References

    • Zeynizadeh, Behzad; Kouhkan, Mehri Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 9 p. 3448 - 3452
  • Route2

    References

    • SYNTHON BV; DYMACEK, Bohumil Patent: WO2012/116752 A1, 2012 ; Location in patent: Page/Page column 13 ;
  • Route3
    • 1-Indanone Rasagiline  Impurity|CS-0229098
      83-33-0
    • ~90%
    • In-stock
      1-Aminoindan|CS-W007551
      34698-41-4

    References

    • Talwar, Dinesh; Salguero, Noemi Poyatos; Robertson, Craig M.; Xiao, Jianliang Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 245 - 252

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.6326
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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