tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

Name: tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 934536-10-4
Cat. No. CS-0048229
Purity≥95%
MDL No.MFCD10566556

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate|CS-0048229

Structure of 934536-10-4

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General Information

CAS No. 934536-10-4
Cat. No. CS-0048229
Purity ≥95%
MDL No. MFCD10566556
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉FN₂O₂
Molecular Weight 218.27
Synonym(s) 4-AMino-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester
SMILES CC(C)(C)OC(=O)N1CCC(N)C(F)C1

Description

tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate delivers a fluorinated piperidine scaffold with a readily manipulable amino group, enabling direct functionalization in medicinal chemistry. The tert-butyl carbamate protects the amine under standard conditions while maintaining compatibility with diverse transformations. This derivative supports efficient synthesis of bioactive compounds featuring constrained, electron-deficient heterocycles.

Application

tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated piperidine scaffolds. The protected amine and fluorinated C3 position facilitate downstream functionalization via standard coupling, reduction, and electrophilic substitution reactions. Its bench-stable tert-butyl carbamate group simplifies purification and offers orthogonal reactivity, making it well-suited for iterative synthesis of bioactive molecules.

Synthesis

Route1
- 934536-09-1
- ~%
- In-stock
  
  934536-10-4
References
- Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Patent: US2010/324030 A1, 2010 ; Location in patent: Page/Page column 22 ;
Route2
- 211108-48-4
- ~%
- In-stock
  
  934536-10-4
References
- ASTRAZENECA AB Patent: WO2005/90330 A1, 2005 ; Location in patent: Page/Page column 78-79 ; WO 2005/090330 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 1.2926
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

CAS No. 934536-10-4

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