(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

Name: (3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1260612-08-5
Cat. No. CS-0058589
Purity≥98%
MDL No.MFCD12756122

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate|CS-0058589

Structure of 1260612-08-5

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Description

This chiral piperidine derivative features a bench-stable tert-butyl carbamate protecting group and a fluorinated ring system, enabling direct incorporation into complex scaffolds. The (3R,4R) stereochemistry ensures predictable diastereoselective transformations in medicinal chemistry workflows.

Application

(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds prevalent in medicinal chemistry. The protected amine and fluorine substituent enable selective functionalization, while the tert-butyl carbamate group offers stability and ease of removal under mild acidic conditions. This compound facilitates efficient access to complex nitrogen-containing heterocycles and is well-suited for iterative synthesis workflows requiring orthogonal reactivity and bench-stable intermediates.

General Information

CAS No. 1260612-08-5
Cat. No. CS-0058589
Purity ≥98%
MDL No. MFCD12756122
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉FN₂O₂
Molecular Weight 218.27
Synonym(s) tert-butyl (3R,4R)-4-aMino-3-fluoropiperidine-1-carboxylate
SMILES F[C@H]1[C@H](N)CCN(C(OC(C)(C)C)=O)C1

Computational Chemistry Data

TPSA 55.56
LogP 1.2926
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(3R,4R)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate

CAS No. 1260612-08-5

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