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CS-W001157 4
Total: USD 88.00

3,3-Difluoropiperidine hydrochloride

  • CAS No. 496807-97-7

  • Cat. No. CS-W001579
  • Purity≥97%
  • MDL No.MFCD03452800
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,3-Difluoropiperidine hydrochloride|CS-W001579

Structure of 496807-97-7

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Description

3,3-Difluoropiperidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring two fluorine atoms at the 3-position of the piperidine ring. This electron-deficient scaffold enhances metabolic stability and modulates basicity, enabling efficient incorporation into bioactive molecules. The hydrochloride salt form ensures excellent solubility and ease of handling in synthetic workflows.

Application

3,3-Difluoropiperidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the incorporation of fluorinated piperidine motifs into bioactive molecules. Its difluoromethylene group enhances metabolic stability and modulates lipophilicity. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in standard synthetic workflows. It functions effectively in amine coupling reactions and as a scaffold for constructing complex heterocyclic systems.

General Information

  • CAS No. 496807-97-7
  • Cat. No. CS-W001579
  • Purity ≥97%
  • MDL No. MFCD03452800
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClF₂N
  • Molecular Weight 157.59
  • Synonym(s) Piperidine, 3,3-difluoro-, hydrochloride
  • SMILES FC1(F)CNCCC1.[H]Cl

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4269
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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