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CS-W001157 4
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3,3-Difluoropiperidine hydrochloride

  • CAS No. 496807-97-7

  • Cat. No. CS-W001579
  • Molecule weight157.59
  • Purity≥97%
  • MDL No.MFCD03452800

*For research and further manufacturing use only, not for direct human use.

3,3-Difluoropiperidine hydrochloride|CS-W001579

Structure of 496807-97-7

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General Information

  • CAS No. 496807-97-7
  • Cat. No. CS-W001579
  • Purity ≥97%
  • MDL No. MFCD03452800
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClF₂N
  • Molecular Weight 157.59
  • Synonym(s) Piperidine, 3,3-difluoro-, hydrochloride
  • SMILES FC1(F)CNCCC1.[H]Cl

Description

3,3-Difluoropiperidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring two fluorine atoms at the 3-position of the piperidine ring. This electron-deficient scaffold enhances metabolic stability and modulates basicity, enabling efficient incorporation into bioactive molecules. The hydrochloride salt form ensures excellent solubility and ease of handling in synthetic workflows.

Application

3,3-Difluoropiperidine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the incorporation of fluorinated piperidine motifs into bioactive molecules. Its difluoromethylene group enhances metabolic stability and modulates lipophilicity. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in standard synthetic workflows. It functions effectively in amine coupling reactions and as a scaffold for constructing complex heterocyclic systems.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4269
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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