tert-Butyl 3,3-difluoropiperidine-1-carboxylate

Name: tert-Butyl 3,3-difluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 911634-75-8
Cat. No. CS-W001679
Molecule weight221.24
Purity≥97%
MDL No.MFCD11054112

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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tert-Butyl 3,3-difluoropiperidine-1-carboxylate|CS-W001679

Structure of 911634-75-8

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General Information

CAS No. 911634-75-8
Cat. No. CS-W001679
Purity ≥97%
MDL No. MFCD11054112
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₇F₂NO₂
Molecular Weight 221.24
Synonym(s) 1-BOC-3,3-DIFLUOROPIPERIDINE
SMILES O=C(N1CCCC(C1)(F)F)OC(C)(C)C

Description

tert-Butyl 3,3-difluoropiperidine-1-carboxylate is a bench-stable, moisture-tolerant building block featuring a sterically hindered piperidine core with two fluorine atoms at the 3-position. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns requiring enhanced metabolic stability and modulated basicity.

Application

tert-Butyl 3,3-difluoropiperidine-1-carboxylate serves as a stable, bench-ready building block for the synthesis of fluorinated piperidine scaffolds. The difluoro substitution at the C3 position imparts enhanced metabolic stability and modulates basicity, enabling access to bioactive molecules in medicinal chemistry. Its tert-butyl carbamate group facilitates straightforward deprotection under mild acidic conditions, while the core structure tolerates a range of standard coupling and functionalization reactions, making it a practical choice for iterative synthesis workflows.

Synthesis

Route1
- In-stock
  
  98977-36-7
- ~64%
- In-stock
  
  911634-75-8
References
- LG LIFE SCIENCES, LTD. Patent: WO2006/104356 A1, 2006 ; Location in patent: Page/Page column 35 ; WO 2006/104356 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P210-P264-P280-P302+P352-P362+P364-P370+P378-P403-P501

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Computational Chemistry Data

TPSA 29.54
LogP 2.6526
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 3,3-difluoropiperidine-1-carboxylate

CAS No. 911634-75-8

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