tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate

Name: tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1228185-45-2
Cat. No. CS-0048529
Purity≥97%
MDL No.MFCD26516106

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate|CS-0048529

Structure of 1228185-45-2

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Description

tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate delivers a stereochemically defined fluorinated piperidine scaffold with enhanced metabolic stability. The tert-butyl ester group enables straightforward deprotection under mild acidic conditions, while the amino and fluorine substituents provide strategic handle points for diversification in medicinal chemistry campaigns.

Application

tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of fluorinated piperidine-containing pharmaceuticals. The protected amine and fluorinated C3 position enable direct functionalization in late-stage diversification, while the tert-butyl carbamate group offers excellent bench stability and facile deprotection under mild acidic conditions. Its well-defined stereochemistry facilitates reproducible access to bioactive scaffolds in medicinal chemistry campaigns.

General Information

CAS No. 1228185-45-2
Cat. No. CS-0048529
Purity ≥97%
MDL No. MFCD26516106
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉FN₂O₂
Molecular Weight 218.27
Synonym(s) (3S,4S)-tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate
SMILES CC(C)(OC(N1CC[C@@H]([C@H](C1)F)N)=O)C

Computational Chemistry Data

TPSA 55.56
LogP 1.2926
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate

CAS No. 1228185-45-2

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