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CS-W001157 4
Total: USD 88.00

5-Ethynylthiazole

  • CAS No. 872122-41-3

  • Cat. No. CS-0528673
  • Purity≥95%
  • MDL No.MFCD16878697
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Ethynylthiazole|CS-0528673

Structure of 872122-41-3

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Description

5-Ethynylthiazole is a bench-stable, moisture-tolerant heterocyclic building block featuring a terminal alkyne group. This functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer synthesis. The electron-deficient thiazole ring enhances reactivity in cross-coupling processes, enabling seamless integration into complex molecular architectures.

Application

5-Ethynylthiazole serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized heterocycles via copper-catalyzed coupling reactions. The terminal alkyne group exhibits high reactivity in Sonogashira and click-type transformations, while the thiazole core provides metabolic stability and favorable electronic properties. Bench-stable and readily purified by column chromatography, it functions as a key scaffold component in the synthesis of bioactive molecules and conjugated systems.

General Information

  • CAS No. 872122-41-3
  • Cat. No. CS-0528673
  • Purity ≥95%
  • MDL No. MFCD16878697
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃NS
  • Molecular Weight 109.15
  • Synonym(s) Thiazole, 5-ethynyl-
  • SMILES C#CC1=CN=CS1

Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.1244
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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