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CS-W001157 4
Total: USD 88.00

5-Ethynylthiazole

  • CAS No. 872122-41-3

  • Cat. No. CS-0528673
  • Molecule weight109.15
  • Purity≥95%
  • MDL No.MFCD16878697

*For research and further manufacturing use only, not for direct human use.

5-Ethynylthiazole|CS-0528673

Structure of 872122-41-3

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General Information

  • CAS No. 872122-41-3
  • Cat. No. CS-0528673
  • Purity ≥95%
  • MDL No. MFCD16878697
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃NS
  • Molecular Weight 109.15
  • Synonym(s) Thiazole, 5-ethynyl-
  • SMILES C#CC1=CN=CS1

Description

5-Ethynylthiazole is a bench-stable, moisture-tolerant heterocyclic building block featuring a terminal alkyne group. This functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer synthesis. The electron-deficient thiazole ring enhances reactivity in cross-coupling processes, enabling seamless integration into complex molecular architectures.

Application

5-Ethynylthiazole serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized heterocycles via copper-catalyzed coupling reactions. The terminal alkyne group exhibits high reactivity in Sonogashira and click-type transformations, while the thiazole core provides metabolic stability and favorable electronic properties. Bench-stable and readily purified by column chromatography, it functions as a key scaffold component in the synthesis of bioactive molecules and conjugated systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.1244
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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