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5-Methylthiazole-2-carboxylic acid

  • CAS No. 61291-21-2

  • Cat. No. CS-0030600
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Methylthiazole-2-carboxylic acid|CS-0030600

Structure of 61291-21-2

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General Information

  • CAS No. 61291-21-2
  • Cat. No. CS-0030600
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight 143.16
  • Synonym(s) Sodium 5-methyl-1,3-thiazole-2-carboxylate
  • SMILES O=C(C1=NC=C(C)S1)O

Description

5-Methylthiazole-2-carboxylic acid features a thiazole core with complementary electron-rich and electron-deficient moieties, enabling versatile integration into pharmaceutical scaffolds. The carboxylic acid group facilitates direct conjugation or derivatization under standard conditions, while the methyl substituent enhances lipophilicity and metabolic stability in bioactive molecule design.

Application

5-Methylthiazole-2-carboxylic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to thiazole-based scaffolds. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the methyl group provides a site for selective functionalization. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for scalable synthesis workflows.

Synthesis

  • Route1

    References

    • US6472404 B1, ;
  • Route2
    • Ethyl 5-methylthiazole-2-carboxylate|CS-0667918
      58334-08-0
    • ~%
    • In-stock
      5-Methylthiazole-2-carboxylic acid|CS-0030600
      61291-21-2

    References

    • Nippon Kagaku Zasshi, , vol. 80, p. 1021,1023 Chem.Abstr., , p. 5467

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.14972
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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