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CS-W001157 4
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5-AIQ hydrochloride

  • CAS No. 93117-07-8

  • Cat. No. CS-0142460
  • Purity≥98%
  • MDL No.MFCD03452659

*For research and further manufacturing use only, not for direct human use.

5-AIQ hydrochloride|CS-0142460

Structure of 93117-07-8

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General Information

  • CAS No. 93117-07-8
  • Cat. No. CS-0142460
  • Purity ≥98%
  • MDL No. MFCD03452659
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉ClN₂O
  • Molecular Weight 196.63
  • Synonym(s) 5-Aminoisoquinolin-1-one (hydrochloride)
  • SMILES O=C1NC=CC2=C1C=CC=C2N.Cl

Description

Inhibiting PARP-1 activity through covalent adduct formation, 5-AIQ hydrochloride (CAS 93117-07-8) suppresses excessive DNA repair consumption and reduces oxidative stress-induced hepatocyte necrosis in ischemia-reperfusion models.

Application

5-AIQ hydrochloride (CAS 93117-07-8) inhibits poly (ADP-ribose) polymerase-1 (PARP-1) with high specificity, disrupting DNA damage response pathways in cancer cells. This inhibition triggers antiangiogenic effects. Researchers leverage this property to explore novel therapeutic strategies for solid tumors and retinal vascular disorders.

Synthesis

  • Route1

    References

    • Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2049 - 2059
  • Route2

    References

    • Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2049 - 2059
  • Route3

    References

    • Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2049 - 2059

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.88
  • LogP   1.5321
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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