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CS-W001157 4
Total: USD 88.00

5-Methyl-2-phenylpyridine

  • CAS No. 27012-22-2

  • Cat. No. CS-0085797
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-phenylpyridine|CS-0085797

Structure of 27012-22-2

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Description

5-Methyl-2-phenylpyridine is a bench-stable, electron-rich heterocycle featuring a para-substituted phenyl group and a methyl moiety at the 5-position. This configuration enhances π-conjugation and stabilizes coordination to transition metals, enabling its use in catalytic systems requiring robust ligand frameworks.

Application

5-Methyl-2-phenylpyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling the efficient construction of biaryl and heteroaryl scaffolds. Its electron-rich pyridine core facilitates palladium- and nickel-catalyzed coupling with aryl halides and pseudohalides, while the methyl and phenyl substituents provide steric and electronic modulation. The compound exhibits excellent bench stability, simplifies purification, and functions effectively in both small-molecule synthesis and medicinal chemistry campaigns requiring modular heterocyclic frameworks.

General Information

  • CAS No. 27012-22-2
  • Cat. No. CS-0085797
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁N
  • Molecular Weight 169.22
  • Synonym(s) 6-Phenyl-3-picoline
  • SMILES CC1=CN=C(C2=CC=CC=C2)C=C1

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.05702
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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