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Structure of 27012-22-2
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5-Methyl-2-phenylpyridine is a bench-stable, electron-rich heterocycle featuring a para-substituted phenyl group and a methyl moiety at the 5-position. This configuration enhances π-conjugation and stabilizes coordination to transition metals, enabling its use in catalytic systems requiring robust ligand frameworks.
5-Methyl-2-phenylpyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling the efficient construction of biaryl and heteroaryl scaffolds. Its electron-rich pyridine core facilitates palladium- and nickel-catalyzed coupling with aryl halides and pseudohalides, while the methyl and phenyl substituents provide steric and electronic modulation. The compound exhibits excellent bench stability, simplifies purification, and functions effectively in both small-molecule synthesis and medicinal chemistry campaigns requiring modular heterocyclic frameworks.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: