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tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

  • CAS No. 923009-50-1

  • Cat. No. CS-W020526
  • Molecule weight254.33
  • Purity≥95%
  • MDL No.MFCD11227060

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate|CS-W020526

Structure of 923009-50-1

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General Information

  • CAS No. 923009-50-1
  • Cat. No. CS-W020526
  • Purity ≥95%
  • MDL No. MFCD11227060
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₂N₂O₃
  • Molecular Weight 254.33
  • Synonym(s) tert-Butyl 4-oxo-3,9-diazaspiro[4.5]decane-9-carboxylate - B0957
  • SMILES O=C(OC(C)(C)C)N1CC2(CCC1)C(NCC2)=O

Description

tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate features a rigid spirocyclic core with strategically positioned carbonyl and amine functionalities, enabling efficient integration into complex heterocyclic scaffolds. This bench-stable, moisture-tolerant building block facilitates streamlined synthesis of bioactive nitrogen-containing frameworks.

Application

tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate serves as a versatile spirocyclic scaffold for the synthesis of nitrogen-containing heterocycles, enabling efficient access to complex alkaloid-like architectures. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate straightforward derivatization. The tert-butyl ester moiety allows for convenient deprotection in mild acidic environments, making it ideal for late-stage functionalization in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • 1,3-Piperidinedicarboxylic Acid, 3-(Cyanomethyl)-, 1-(1,1-Dimethylethyl) 3-Ethyl Ester|CS-0038710
      923009-49-8
    • ~%
    • In-stock
      tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate|CS-W020526
      923009-50-1

    References

    • Yamashita, Tohru; Kamata, Makoto; Endo, Satoshi; Yamamoto, Mitsuo; Kakegawa, Keiko; Watanabe, Hiroyuki; Miwa, Katsuhiko; Yamano, Toru; Funata, Masaaki; Sakamoto, Jyun-Ichi; Tani, Akiyoshi; Mol, Clifford D.; Zou, Hua; Dougan, Douglas R.; Sang, BiChing; Snell, Gyorgy; Fukatsu, Kohji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6314 - 6318
  • Route2
    • null|null
      148672-74-6
    • ~%
    • In-stock
      tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate|CS-W020526
      923009-50-1

    References

    • Yamashita, Tohru; Kamata, Makoto; Endo, Satoshi; Yamamoto, Mitsuo; Kakegawa, Keiko; Watanabe, Hiroyuki; Miwa, Katsuhiko; Yamano, Toru; Funata, Masaaki; Sakamoto, Jyun-Ichi; Tani, Akiyoshi; Mol, Clifford D.; Zou, Hua; Dougan, Douglas R.; Sang, BiChing; Snell, Gyorgy; Fukatsu, Kohji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6314 - 6318
  • Route3
    • 1,3-Piperidinedicarboxylic Acid, 3-(Cyanomethyl)-, 1-(1,1-Dimethylethyl) 3-Ethyl Ester|CS-0038710
      923009-49-8
    • ~%
    • In-stock
      tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate|CS-W020526
      923009-50-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6314 - 6318

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   1.5236
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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