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Structure of 454-79-5
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2-Bromo-5-(trifluoromethyl)aniline was used in the synthesis and biochemical evaluation of series of inhibitors of hepatitis C virus (HCV) NS3 protease.
2-Bromo-5-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions such as Suzuki and Buchwald-Hartwig couplings. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the bromo substituent provides a reliable handle for further functionalization. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for scalable, reproducible synthetic workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3267
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: