(R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone

Name: (R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone
Brand: ChemScene
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CAS No. 916733-17-0
Cat. No. CS-0052712
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone|CS-0052712

Structure of 916733-17-0

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Description

(R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone is a chiral building block featuring a hydroxylated pyrrolidine ring attached to an acetyl group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry applications where stereochemistry influences target engagement. The molecule exhibits favorable solubility and stability under standard bench conditions, facilitating its use in synthetic workflows requiring precise stereoselective control.

Application

(R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide mimetics. The hydroxypyrrolidine moiety offers enhanced solubility and metabolic stability, while the ketone functionality supports efficient derivatization via nucleophilic addition, reductive amination, or enolate chemistry. Bench-stable and readily purified by chromatography, it functions as a key scaffold for targeted molecular libraries in drug discovery workflows.

General Information

CAS No. 916733-17-0
Cat. No. CS-0052712
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁NO₂
Molecular Weight 129.16
Synonym(s) (R)-1-Acetyl-3-hydroxypyrrolidine
SMILES CC(=O)N1CC[C@@H](O)C1

Computational Chemistry Data

TPSA 40.54
LogP -0.4005
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(3-Hydroxypyrrolidin-1-yl)ethanone

CAS No. 916733-17-0

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