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CS-W001157 4
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3-(Aminomethyl)benzo[b]thiophene

  • CAS No. 40615-04-1

  • Cat. No. CS-0156019
  • Purity≥95%
  • MDL No.MFCD00176440

*For research and further manufacturing use only, not for direct human use.

3-(Aminomethyl)benzo[b]thiophene|CS-0156019

Structure of 40615-04-1

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General Information

  • CAS No. 40615-04-1
  • Cat. No. CS-0156019
  • Purity ≥95%
  • MDL No. MFCD00176440
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NS
  • Molecular Weight 163.24
  • Synonym(s) 1-(1-Benzothiophen-3-Yl)methanamine
  • SMILES C1=CC=C2C(=C1)C(=CS2)CN

Description

3-(Aminomethyl)benzo[b]thiophene features a benzothiophene core with a strategically positioned aminomethyl side chain, enabling facile functionalization in medicinal chemistry. This scaffold integrates well into bioactive molecules, offering favorable solubility and metabolic stability for target-directed probe development.

Application

3-(Aminomethyl)benzo[b]thiophene serves as a versatile building block for the synthesis of biologically active heterocycles, enabling direct functionalization at the benzo[b]thiophene core. The pendant primary amine facilitates conjugation, protection, or derivatization in standard peptide and medicinal chemistry workflows. Its bench-stable nature and compatibility with diverse reaction conditions support scalable synthesis and purification, making it well-suited for scaffold-hopping studies and API development.

Synthesis

  • Route1
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    • In-stock
      3-(Aminomethyl)benzo[b]thiophene|CS-0156019
      40615-04-1

    References

    • Pedras, M. Soledade C.; Hossain, Mohammad Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5981 - 5996

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.36
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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