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Furan-3-ylmethanamine

  • CAS No. 4543-47-9

  • Cat. No. CS-0155527
  • Purity≥98%
  • MDL No.MFCD02681983

*For research and further manufacturing use only, not for direct human use.

Furan-3-ylmethanamine|CS-0155527

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General Information

  • CAS No. 4543-47-9
  • Cat. No. CS-0155527
  • Purity ≥98%
  • MDL No. MFCD02681983
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NO
  • Molecular Weight 97.12
  • Synonym(s) 3-FURYLMETHYLAMINE
  • SMILES C1=COC=C1CN

Description

Furan-3-ylmethanamine delivers a reactive furan-bearing aliphatic amine for molecular integration. This bench-stable, moisture-tolerant scaffold features a pendant primary amine that facilitates conjugation with electrophiles, enabling rapid access to functionalized heterocycles in synthetic and medicinal chemistry workflows.

Application

Furan-3-ylmethanamine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization protocols. Its furan moiety provides structural rigidity and favorable electronic properties, while the primary amine facilitates conjugation with carbonyl electrophiles, sulfonamides, and other reagents. The compound exhibits good bench stability and is readily purified by standard techniques, making it well-suited for use in iterative synthesis campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Katsura, Yousuke; Nishino, Shigetaka; Ohno, Mitsuko; Sakane, Kazuo; Matsumoto, Yoshimi; Morinaga, Chizu; Ishikawa, Hirohumi; Takasugi, Hisashi Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2920 - 2926
  • Route2

    References

    • The Dow Chemical Company Patent: US5505931 A1, 1996 ;
  • Route3
    • null|null
      30078-65-0
    • ~99%
    • In-stock
      Furan-3-ylmethanamine|CS-0155527
      4543-47-9

    References

    • Enthaler, Stephan; Addis, Daniele; Junge, Kathrin; Erre, Giulia; Beller, Matthias Chemistry - A European Journal, 2008 , vol. 14, # 31 p. 9491 - 9494

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2733
Class : 3 (8)
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.16
  • LogP   0.7383
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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