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CS-W001157 4
Total: USD 88.00

4-Aminotetrahydro-2H-thiopyran 1,1-dioxide

  • CAS No. 210240-20-3

  • Cat. No. CS-0012628
  • Purity≥97%
  • MDL No.MFCD09540491

*For research and further manufacturing use only, not for direct human use.

4-Aminotetrahydro-2H-thiopyran 1,1-dioxide|CS-0012628

Structure of 210240-20-3

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General Information

  • CAS No. 210240-20-3
  • Cat. No. CS-0012628
  • Purity ≥97%
  • MDL No. MFCD09540491
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂S
  • Molecular Weight 149.21
  • Synonym(s) Tetrahydro-2H-thiopyran-4-amine 1,1-dioxide
  • SMILES NC(CC1)CCS1(=O)=O

Description

4-Aminotetrahydro-2H-thiopyran 1,1-dioxide features a saturated thiopyran ring with dual sulfone functionalities, delivering enhanced polarity and metabolic stability. The primary amine enables direct derivatization, while the electron-withdrawing sulfones modulate reactivity. This scaffold serves as a robust building block for bioactive molecule synthesis, particularly in medicinal chemistry where solubility and stability are critical.

Application

4-Aminotetrahydro-2H-thiopyran 1,1-dioxide serves as a versatile sulfonamide-containing scaffold in medicinal chemistry, offering a rigid, polar heterocyclic core with excellent functional group tolerance. The amine functionality enables facile derivatization via amidation, alkylation, or acylation, while the sulfonyl group enhances solubility and metabolic stability. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for building diverse compound libraries in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335-H411
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -0.4777
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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