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CS-W001157 4
Total: USD 88.00

4-(1-Hydroxyethyl)pyridine

  • CAS No. 23389-75-5

  • Cat. No. CS-W011188
  • Purity≥98%
  • MDL No.MFCD00077867

*For research and further manufacturing use only, not for direct human use.

4-(1-Hydroxyethyl)pyridine|CS-W011188

Structure of 23389-75-5

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General Information

  • CAS No. 23389-75-5
  • Cat. No. CS-W011188
  • Purity ≥98%
  • MDL No. MFCD00077867
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO
  • Molecular Weight 123.16
  • Synonym(s) alpha-Methylpyridine-4-methanol
  • SMILES CC(C1=CC=NC=C1)O

Description

4-(1-Hydroxyethyl)pyridine features a pyridine ring functionalized with a hydroxyethyl side chain, delivering enhanced solubility and reactivity. This bench-stable compound integrates readily into synthetic routes requiring polar, nitrogen-containing motifs. The pendant hydroxyl group enables further derivatization through etherification or oxidation, supporting applications in medicinal chemistry and ligand design.

Application

4-(1-Hydroxyethyl)pyridine serves as a versatile pyridyl building block for medicinal chemistry and catalytic synthesis. The tertiary alcohol functionality enables direct derivatization via esterification, etherification, or oxidation to the corresponding ketone. Its stability under standard bench conditions and compatibility with common coupling reactions facilitate integration into complex molecular architectures. Functions as a key intermediate in the construction of bioactive heterocycles and functionalized pharmaceutical scaffolds.

Synthesis

  • Route1
    • 1-(Pyridin-4-yl)ethanone  Imatinib Impurity|CS-0167015
      1122-54-9
    • ~10%
    • In-stock
      4-(1-Hydroxyethyl)pyridine|CS-W011188
      23389-75-5

    References

    • Yu, Jin-Quan; Wu, Hai-Chen; Ramarao, Chandrashekar; Spencer, Jonathan B; Ley, Steven V Chemical communications (Cambridge, England), 2003 , # 6 p. 678 - 679
  • Route2
    • 1-(Pyridin-4-yl)ethanone  Imatinib Impurity|CS-0167015
      1122-54-9
    • null|null
      75-29-6
    • ~7%
    • In-stock
      4-(1-Hydroxyethyl)pyridine|CS-W011188
      23389-75-5
    • null|null
      37486-32-1

    References

    • Journal of the American Chemical Society, , vol. 128, # 31 p. 9998 - 9999
  • Route3
    • In-stock
      γ-Formylpyridine|CS-D1135
      872-85-5
    • null|null
      75-16-1
    • ~22%
    • In-stock
      4-(1-Hydroxyethyl)pyridine|CS-W011188
      23389-75-5

    References

    • NISSAN CHEMICAL INDUSTRIES, LTD. Patent: WO2009/57827 A1, 2009 ; Location in patent: Page/Page column 120-121 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.1349
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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