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CS-W001157 4
Total: USD 88.00

(4-Fluoro-3-hydroxyphenyl)boronic acid

  • CAS No. 913835-74-2

  • Cat. No. CS-W018015
  • Molecule weight155.92
  • Purity≥97%
  • MDL No.MFCD08689483

*For research and further manufacturing use only, not for direct human use.

(4-Fluoro-3-hydroxyphenyl)boronic acid|CS-W018015

Structure of 913835-74-2

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General Information

  • CAS No. 913835-74-2
  • Cat. No. CS-W018015
  • Purity ≥97%
  • MDL No. MFCD08689483
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) boronic acid, B-(4-fluoro-3-hydroxyphenyl)-
  • SMILES FC1=C(C=C(C=C1)B(O)O)O

Description

This boronic acid features a fluorinated phenyl ring with a strategically positioned hydroxyl group, enhancing solubility and reactivity in Suzuki-Miyaura coupling reactions. The electron-withdrawing fluorine substituent improves stability and directs regioselective functionalization.

Application

(4-Fluoro-3-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation with aryl and vinyl halides. Its hydroxyl group provides enhanced solubility and facilitates downstream derivatization, while the fluorine substituent offers metabolic stability and modulates electronic properties. The boronic acid moiety exhibits excellent bench stability and compatibility with diverse reaction conditions, making it a reliable reagent for constructing complex phenolic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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