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CS-W001157 4
Total: USD 88.00

(3-Fluoro-5-hydroxyphenyl)boronic acid

  • CAS No. 871329-82-7

  • Cat. No. CS-W000995
  • Molecule weight155.92
  • Purity≥98%
  • MDL No.MFCD07363778

*For research and further manufacturing use only, not for direct human use.

(3-Fluoro-5-hydroxyphenyl)boronic acid|CS-W000995

Structure of 871329-82-7

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General Information

  • CAS No. 871329-82-7
  • Cat. No. CS-W000995
  • Purity ≥98%
  • MDL No. MFCD07363778
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) 3-Fluoro-5-hydroxyphenylboronic acid
  • SMILES Oc1cc(F)cc(c1)B(O)O

Description

This boronate moiety features a para-hydroxyl group flanked by a meta-fluorine substituent, delivering enhanced stability and solubility in aqueous-organic mixtures. The electron-deficient aryl ring facilitates efficient Suzuki-Miyaura cross-coupling under mild conditions, enabling precise C–C bond formation in complex molecule synthesis.

Application

(3-Fluoro-5-hydroxyphenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient access to fluorinated aryl scaffolds. The ortho-fluoro and para-hydroxyl groups provide enhanced regiocontrol and functional group tolerance, facilitating downstream derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in the synthesis of biologically relevant heterocycles and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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