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CS-W001157 4
Total: USD 88.00

(5-Chloro-2,4-difluorophenyl)boronic acid

  • CAS No. 911645-24-4

  • Cat. No. CS-0102014
  • Purity≥95%
  • MDL No.MFCD04038751

*For research and further manufacturing use only, not for direct human use.

(5-Chloro-2,4-difluorophenyl)boronic acid|CS-0102014

Structure of 911645-24-4

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General Information

  • CAS No. 911645-24-4
  • Cat. No. CS-0102014
  • Purity ≥95%
  • MDL No. MFCD04038751
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BClF₂O₂
  • Molecular Weight 192.36
  • Synonym(s) 5-Chloro-2,4-Difluorobenzeneboronic Acid
  • SMILES OB(C1=CC(Cl)=C(F)C=C1F)O

Description

This boronic acid features a trifluorinated aryl core with strategic chlorine and fluorine substituents, enabling efficient cross-coupling reactions. The electron-deficient ring enhances reactivity in Suzuki-Miyaura transformations, while the bench-stable nature simplifies handling and integration into complex synthetic sequences.

Application

(5-Chloro-2,4-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro and meta-chloro substituents enhance stability and modulate reactivity, while the boronic acid group offers excellent bench stability and ease of purification. Functions reliably in the construction of fluorinated aromatic scaffolds common in agrochemicals and pharmaceuticals.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.298
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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