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CS-W001157 4
Total: USD 88.00

MCH-1 antagonist 2

  • CAS No. 345-24-4

  • Cat. No. CS-0097033
  • Purity≥95%
  • MDL No.MFCD00129166

*For research and further manufacturing use only, not for direct human use.

MCH-1 antagonist 2|CS-0097033

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General Information

  • CAS No. 345-24-4
  • Cat. No. CS-0097033
  • Purity ≥95%
  • MDL No. MFCD00129166
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrF₂NO₂
  • Molecular Weight 237.99
  • Synonym(s) None
  • SMILES BrC(C=C1[N+]([O-])=O)=C(C=C1F)F

Description

5-Bromo-2,4-difluoronitrobenzene features a nitro group flanked by two fluorine atoms and a bromine substituent, creating a highly reactive aryl halide scaffold. This electron-deficient system enables efficient coupling in cross-coupling reactions, particularly under palladium catalysis. The molecule's stability under standard conditions supports reliable use in synthetic sequences for pharmaceutical intermediates and functional materials.

Application

5-Bromo-2,4-difluoronitrobenzene serves as a versatile building block in nucleophilic aromatic substitution (SNAr) reactions, enabling efficient access to functionalized arylamines and heterocycles. The ortho-fluoro groups facilitate selective displacement under mild conditions, while the bromo and nitro substituents provide orthogonal reactivity for downstream coupling processes. Bench-stable and readily purified by recrystallization, it functions reliably in the synthesis of pharmaceutical intermediates and advanced materials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.6355
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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