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CS-W001157 4
Total: USD 88.00

(3-Chloro-2,4-difluorophenyl)boronic acid

  • CAS No. 1310384-18-9

  • Cat. No. CS-0174392
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-2,4-difluorophenyl)boronic acid|CS-0174392

Structure of 1310384-18-9

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General Information

  • CAS No. 1310384-18-9
  • Cat. No. CS-0174392
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BClF₂O₂
  • Molecular Weight 192.36
  • Synonym(s) 3-Chloro-2,4-difluorophenylboronic acid
  • SMILES OB(O)C1=C(F)C(Cl)=C(F)C=C1

Description

This boronate moiety features a trifluorinated aryl scaffold with orthogonal halogen handles, enabling selective cross-coupling under standard conditions. The chlorine and fluorine substituents enhance electrophilic reactivity while maintaining bench-stability and compatibility with diverse catalytic systems.

Application

(3-Chloro-2,4-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro and chloro substituents enhance electrophilic reactivity while maintaining bench stability and compatibility with diverse functional groups. The compound facilitates the synthesis of complex arylated scaffolds commonly found in pharmaceutical intermediates and agrochemicals.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.298
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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