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CS-W001157 4
Total: USD 88.00

(2-Amino-3-fluorophenyl)methanol

  • CAS No. 906811-49-2

  • Cat. No. CS-0157223
  • Purity≥98%
  • MDL No.MFCD12923270

*For research and further manufacturing use only, not for direct human use.

(2-Amino-3-fluorophenyl)methanol|CS-0157223

Structure of 906811-49-2

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General Information

  • CAS No. 906811-49-2
  • Cat. No. CS-0157223
  • Purity ≥98%
  • MDL No. MFCD12923270
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight None
  • Synonym(s) Benzenemethanol, 2-amino-3-fluoro- (9CI)
  • SMILES C1=CC(=C(C(=C1)F)N)CO

Description

This bench-stable arylmethanol features a fluorinated aromatic ring paired with an ortho-amino group, enabling direct incorporation into bioactive scaffolds. The primary alcohol facilitates derivatization under mild conditions, while the electron-withdrawing fluorine enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates.

Application

(2-Amino-3-fluorophenyl)methanol serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds, enabling efficient construction of heterocycles and bioactive intermediates. Its dual amine and alcohol functionalities provide orthogonal reactivity for selective derivatization, while the ortho-fluoro group facilitates subsequent nucleophilic substitution or transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and is readily purified by standard techniques, making it well-suited for iterative medicinal chemistry campaigns and process-scale applications.

Synthesis

  • Route1

    References

    • AMGEN INC. Patent: US2010/331306 A1, 2010 ; Location in patent: Page/Page column 19 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.9002
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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