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CS-W001157 4
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2-PPA

  • CAS No. 21203-86-1

  • Cat. No. CS-D1566
  • Purity≥97%
  • MDL No.MFCD01646280

*For research and further manufacturing use only, not for direct human use.

2-PPA|CS-D1566

Structure of 21203-86-1

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General Information

  • CAS No. 21203-86-1
  • Cat. No. CS-D1566
  • Purity ≥97%
  • MDL No. MFCD01646280
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂
  • Molecular Weight 170.22
  • Synonym(s) None
  • SMILES NC1=CC(C2=CC=CC=C2)=NC=C1

Description

2-PPA is a bench-stable, moisture-tolerant pyridine derivative featuring a para-substituted phenyl group. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a selective ligand in transition metal catalysis. Its robust functionality enables efficient coupling under standard conditions.

Application

2-PPA serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of substituted pyridines and other heterocyclic scaffolds. Its well-defined reactivity facilitates direct functionalization and coupling processes under mild conditions, offering robust bench stability and straightforward purification. Widely employed in medicinal chemistry and process development, it functions as a reliable precursor for bioactive molecule synthesis.

Synthesis

  • Route1

    References

    • Billingsley, Kelvin L.; Anderson, Kevin W.; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2006 , vol. 45, # 21 p. 3484 - 3488

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.3308
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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