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CS-W001157 4
Total: USD 88.00

4-(1,3-Oxazol-5-yl)aniline

  • CAS No. 1008-95-3

  • Cat. No. CS-0034654
  • Purity≥97%
  • MDL No.MFCD00052192

*For research and further manufacturing use only, not for direct human use.

4-(1,3-Oxazol-5-yl)aniline|CS-0034654

Structure of 1008-95-3

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General Information

  • CAS No. 1008-95-3
  • Cat. No. CS-0034654
  • Purity ≥97%
  • MDL No. MFCD00052192
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) None
  • SMILES NC1=CC=C(C2=CN=CO2)C=C1

Description

4-(1,3-Oxazol-5-yl)aniline integrates a planar oxazole heterocycle with an aromatic amine, delivering enhanced electronic coupling and solubility in polar aprotic solvents. This robust scaffold enables direct incorporation into conjugated systems for materials chemistry and pharmaceutical intermediates.

Application

4-(1,3-Oxazol-5-yl)aniline serves as a versatile building block in medicinal chemistry and materials science, enabling the construction of biologically active heterocycles and functionalized aromatic scaffolds. The molecule combines an electron-rich aniline moiety with a 1,3-oxazole ring, offering enhanced stability and favorable reactivity in coupling reactions. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to complex architectures, including kinase inhibitors and fluorescent probes.

Synthesis

  • Route1

    References

    • F2G LTD Patent: WO2006/123145 A1, 2006 ; Location in patent: Page/Page column 66-67 ;
  • Route2
    • In-stock
      5-(4-Nitrophenyl)-1,3-oxazole|CS-0034957
      1014-23-9
    • null|null
      7439-89-6
    • ~80%
    • In-stock
      4-(1,3-Oxazol-5-yl)aniline|CS-0034654
      1008-95-3

    References

    • Cell Therapeutics, Inc. Patent: US2004/204386 A1, 2004 ;
  • Route3

    References

    • Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain Tetrahedron, 2009 , vol. 65, # 32 p. 6348 - 6353

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.05
  • LogP   1.9238
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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