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CS-W001157 4
Total: USD 88.00

3-(Difluoromethoxy)aniline

  • CAS No. 22236-08-4

  • Cat. No. CS-W008180
  • Purity≥97%
  • MDL No.MFCD00236221
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethoxy)aniline|CS-W008180

Structure of 22236-08-4

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Description

3-(Difluoromethoxy)aniline features a difluoromethoxy group positioned ortho to the amino functionality, imparting enhanced metabolic stability and modulated electronic properties. This electron-withdrawing substituent improves solubility in polar solvents while maintaining compatibility with standard coupling reactions. The molecule serves as a valuable building block for pharmaceutical intermediates and functional materials requiring controlled lipophilicity and reactivity.

Application

3-(Difluoromethoxy)aniline serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group at the meta position of an aromatic ring. Its robust bench stability and compatibility with standard coupling reactions facilitate efficient synthesis of bioactive heterocycles and pharmaceutical intermediates.

General Information

  • CAS No. 22236-08-4
  • Cat. No. CS-W008180
  • Purity ≥97%
  • MDL No. MFCD00236221
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₂NO
  • Molecular Weight 159.13
  • Synonym(s) α,α-Difluoro-m-anisidine
  • SMILES FC(OC1=CC=CC(=C1)N)F

Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.8702
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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