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Structure of 22236-08-4
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3-(Difluoromethoxy)aniline features a difluoromethoxy group positioned ortho to the amino functionality, imparting enhanced metabolic stability and modulated electronic properties. This electron-withdrawing substituent improves solubility in polar solvents while maintaining compatibility with standard coupling reactions. The molecule serves as a valuable building block for pharmaceutical intermediates and functional materials requiring controlled lipophilicity and reactivity.
3-(Difluoromethoxy)aniline serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethoxy group at the meta position of an aromatic ring. Its robust bench stability and compatibility with standard coupling reactions facilitate efficient synthesis of bioactive heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: