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CS-W001157 4
Total: USD 88.00

4-(Difluoromethoxy)benzene-1,2-diamine

  • CAS No. 172282-50-7

  • Cat. No. CS-0157040
  • Molecule weight174.15
  • Purity≥97%
  • MDL No.MFCD15147144

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethoxy)benzene-1,2-diamine|CS-0157040

Structure of 172282-50-7

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General Information

  • CAS No. 172282-50-7
  • Cat. No. CS-0157040
  • Purity ≥97%
  • MDL No. MFCD15147144
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈F₂N₂O
  • Molecular Weight 174.15
  • Synonym(s) Pantoprazole Impurity R
  • SMILES C1=CC(=C(C=C1OC(F)F)N)N

Description

4-(Difluoromethoxy)benzene-1,2-diamine features a bifunctional aromatic core with strategically positioned amino groups and a difluoromethoxy substituent. This electron-rich scaffold enables direct integration into complex molecular architectures, offering enhanced solubility and stability under standard conditions. The para-oriented diamine moiety facilitates efficient coupling reactions in medicinal chemistry and materials synthesis.

Application

4-(Difluoromethoxy)benzene-1,2-diamine serves as a versatile building block for heterocyclic synthesis, enabling the construction of biologically relevant scaffolds through standard cyclization reactions. Its ortho-diamine functionality facilitates efficient imine formation and subsequent ring closure, while the difluoromethoxy group enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with common functional groups, simplifying purification and integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   61.27
  • LogP   1.4524
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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