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CS-W001157 4
Total: USD 88.00

5-(4-Nitrophenyl)-1,3-oxazole

  • CAS No. 1014-23-9

  • Cat. No. CS-0034957
  • Purity≥95%
  • MDL No.MFCD00085148

*For research and further manufacturing use only, not for direct human use.

5-(4-Nitrophenyl)-1,3-oxazole|CS-0034957

Structure of 1014-23-9

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General Information

  • CAS No. 1014-23-9
  • Cat. No. CS-0034957
  • Purity ≥95%
  • MDL No. MFCD00085148
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂O₃
  • Molecular Weight 190.16
  • Synonym(s) 5-(4-Nitrophenyl)oxazole
  • SMILES O=[N+](C1=CC=C(C2=CN=CO2)C=C1)[O-]

Description

5-(4-Nitrophenyl)-1,3-oxazole features a conjugated nitroaryl group fused to a heterocyclic oxazole core, delivering enhanced electron-withdrawing character. This structure enables efficient integration into photoreactive systems and serves as a stable building block for advanced organic synthesis under standard conditions.

Application

5-(4-Nitrophenyl)-1,3-oxazole serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of functionalized heterocycles. Its electron-deficient aryl substituent enhances reactivity in cross-coupling and nucleophilic substitution reactions. The oxazole core offers excellent bench stability, mild purification requirements, and compatibility with diverse functional groups, facilitating integration into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      150619-47-9
    • In-stock
      4-Nitrobenzaldehyde|CS-W007577
      555-16-8
    • ~91%
    • In-stock
      5-(4-Nitrophenyl)-1,3-oxazole|CS-0034957
      1014-23-9

    References

    • NIPPON SODA CO., LTD. Patent: EP1371649 A1, 2003 ; Location in patent: Page 7 ;
  • Route2
    • null|null
      38622-91-2
    • In-stock
      4-Nitrobenzaldehyde|CS-W007577
      555-16-8
    • ~89%
    • In-stock
      5-(4-Nitrophenyl)-1,3-oxazole|CS-0034957
      1014-23-9

    References

    • Cell Therapeutics, Inc. Patent: US2004/204386 A1, 2004 ;
  • Route3
    • null|null
      150619-47-9
    • null|null
      785-80-8
    • ~82%
    • In-stock
      5-(4-Nitrophenyl)-1,3-oxazole|CS-0034957
      1014-23-9

    References

    • NIPPON SODA CO., LTD. Patent: EP1371649 A1, 2003 ; Location in patent: Page 7 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.17
  • LogP   2.2498
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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