Lot numbers can be found on the outside label of a product:
6-(4-Morpholinyl)-3-pyridinamine
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CAS No. 52023-68-4
- Cat. No. CS-0019213
- Purity≥97%
- MDL No.MFCD00119562
*For research and further manufacturing use only, not for direct human use.
Structure of 52023-68-4
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General Information
- CAS No. 52023-68-4
- Cat. No. CS-0019213
- Purity ≥97%
- MDL No. MFCD00119562
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₃N₃O
- Molecular Weight 179.22
- Synonym(s) 2-Morpholino-5-aminopyridine; 3-Amino-6-(morpholin-4-yl)pyridine; 3-Amino-6-(morpholino-4-yl)pyridine; 3-Amino-6-morpholinopyridine; 6-Morpholinopyridin-3-amine
- SMILES NC1=CC=C(N2CCOCC2)N=C1
Description
6-(4-Morpholinyl)-3-pyridinamine features a pyridinamine core functionalized with a morpholine ring at the 6-position, delivering enhanced solubility and metabolic stability. This electron-rich scaffold serves as a key pharmacophore in kinase inhibitor design, enabling effective hydrogen bonding and π-stacking interactions within target binding pockets.
Application
6-(4-Morpholinyl)-3-pyridinamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its pyridinamine core offers enhanced solubility and functional group tolerance, facilitating efficient derivatization in late-stage modifications. The morpholinyl substituent contributes to favorable pharmacokinetic properties, making it valuable for scaffold optimization in drug discovery programs.
Synthesis
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Route1
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In-stock
26820-62-2 - ~99%
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In-stock
52023-68-4
References
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GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory Patent: WO2010/104899 A1, 2010 ; Location in patent: Page/Page column 106 ; WO 2010/104899 A1
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Route2
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In-stock
4548-45-2 - ~%
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In-stock
52023-68-4
References
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SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis Patent: WO2013/126608 A1, 2013 ;
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Route3
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In-stock
4487-59-6 - ~%
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In-stock
52023-68-4
References
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Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J. Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.38
- LogP 0.5004
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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