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CS-W001157 4
Total: USD 88.00

2-Morpholinopyridin-4-amine

  • CAS No. 35980-77-9

  • Cat. No. CS-W021731
  • Purity≥98%
  • MDL No.MFCD02945666

*For research and further manufacturing use only, not for direct human use.

2-Morpholinopyridin-4-amine|CS-W021731

Structure of 35980-77-9

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General Information

  • CAS No. 35980-77-9
  • Cat. No. CS-W021731
  • Purity ≥98%
  • MDL No. MFCD02945666
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃N₃O
  • Molecular Weight 179.22
  • Synonym(s) 2-(4-morpholinyl)-4-pyridinylamine
  • SMILES NC1=CC(=NC=C1)N1CCOCC1

Description

2-Morpholinopyridin-4-amine features a pyridine core functionalized with a morpholine ring and a primary amine at the 4-position, enabling dual-site reactivity. This combination delivers enhanced solubility and tunable basicity, making it valuable for medicinal chemistry applications. The molecule integrates readily into kinase inhibitors and catalytic scaffolds due to its ability to engage in hydrogen bonding and coordinate metal centers.

Application

2-Morpholinopyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to kinase inhibitors and other bioactive heterocycles. Its pyridine core provides a strong hydrogen bond acceptor site, while the morpholine ring enhances solubility and metabolic stability. The amine functionality facilitates straightforward derivatization via coupling reactions, and the molecule exhibits good bench stability and ease of purification—key attributes for scalable synthesis and high-throughput screening workflows.

Synthesis

  • Route1
    • 4-(4-Nitropyridin-2-yl)morpholine|CS-1057775
      848144-27-4
    • ~%
    • In-stock
      2-Morpholinopyridin-4-amine|CS-W021731
      35980-77-9

    References

    • AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L. Patent: WO2012/3283 A1, 2012 ; Location in patent: Page/Page column 154 ; WO 2012/003283 A1
  • Route2
    • null|null
      110-91-8
    • In-stock
      4-Amino-2-chloropyridine|CS-D1410
      14432-12-3
    • ~97%
    • In-stock
      2-Morpholinopyridin-4-amine|CS-W021731
      35980-77-9

    References

    • XCOVERY, INC. Patent: WO2008/88881 A1, 2008 ; Location in patent: Page/Page column 51 ; WO 2008/088881 A1
  • Route3

    References

    • AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L. Patent: WO2012/3283 A1, 2012 ; WO 2012/003283 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.38
  • LogP   0.5004
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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