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CS-W001157 4
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Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

  • CAS No. 89793-11-3

  • Cat. No. CS-0045865
  • Purity≥97%
  • MDL No.MFCD00117906

*For research and further manufacturing use only, not for direct human use.

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate|CS-0045865

Structure of 89793-11-3

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General Information

  • CAS No. 89793-11-3
  • Cat. No. CS-0045865
  • Purity ≥97%
  • MDL No. MFCD00117906
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O₂
  • Molecular Weight 186.60
  • Synonym(s) None
  • SMILES COC(=O)C1=CC(C)=NC(Cl)=N1

Description

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate is a bench-stable pyrimidine derivative featuring a chlorine atom at C2 and a methyl group at C6, enabling selective functionalization. The ester moiety facilitates downstream transformations in medicinal chemistry. This electron-deficient heterocycle integrates readily into complex scaffolds under standard conditions.

Application

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyrimidine-based scaffolds. The ortho-chloro and ester functionalities facilitate palladium-catalyzed cross-coupling reactions and selective derivatization, while the methyl group enhances stability and modulates electronic properties. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for medicinal chemistry campaigns and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   1.22502
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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